
Program - SSSD2019
Wednesday April 10th
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Registration (open from 10:00)
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11.00 - 11.15 Opening with Welcome Remarks from the chair of the local organising committee
Malin Flodström-Tullberg
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11.15 - 12.45 Session 1: Islet physiology and pathophysiology
Chair: Per-Ola Carlsson
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Islet cell exocytosis in type 2 diabetes
Sebastian Barg, Uppsala University, Sweden
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Diabetes from a cellular perspective
Lena Eliasson, Lund University, Sweden
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Oral abstract presentations
Gonzalo Sanchez GABAergic signaling in the primary cilium of pancreatic islet β-
cells
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12.45 - 14.15 Lunch & Exhibition
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13.30 - 14.00 Lunch seminar on scientific publications
Mikael Rydén, Karolinska Institutet, co-editor of Diabetologia
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14.15 - 15.30 Session 1: Islet physiology and pathophysiology (continued)
Chair: Valdemar Grill
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Oral abstract presentations
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Anders Tengholm Glucose-induced changes of α-cell cAMP control glucagon release during hypoglycaemia
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Luis Rodrigo Cataldo PP1R1A, a novel regulator of the GLP1R-amplifying glucose stimulated insulin secretion in β-cells
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Ruifeng Shi The expression and function of Clec11a in human islets
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Hanna Liljebäck Fewer islets survive from first transplantation than second transplantation: evaluation of intraportal islet transplantation in mice
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Anja Brboric Developing techniques for expansion and culture of neural crest stem cells isolated from human bone marrow to improve the survival and function of transplanted islets of Langerhans
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Sara Ullsten Increased susceptibility for immune attack of highly blood perfused, highly metabolically active pancreatic islets
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15.30 - 16.00 Coffee break and exhibition
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16.00 - 17.00 Oral abstract presentations (continued)
Chair: Mikael Rydén
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Type 1 diabetes – clinical aspects
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Anna Korsgaard Berg The economic additional expenditure related to skin problems in patients using insulin pump and/or glucose sensor in a Danish context
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Maarit K Koskinen Longitudinal pattern of first phase insulin response is associated with genetic factors outside class II HLA region in children with multiple autoantibodies
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Anmol Kumar The association between FGF23 and bone mineral density in type 1 diabetes with different stages of renal disease
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Fanny J Jansson High remnant cholesterol predicts progression of diabetic nephropathy in type 1 diabetes
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Marika Eriksson Association between blood pressure measured ambulatory and cerebral small-vessel disease in type 1 diabetes
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17.00 - 18.15 Knud Lundbeck Award lecture:
Chair: Björn Olav Åsvold
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New insights into genetics of metabolic health and disease – lessons to be used in precision medicine
Torben Hansen, University of Copenhagen, Denmark
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18.30 Welcome reception, exhibition
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Thursday April 11th
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08:30 - 09.45 Session 2: Imaging in diabetes
Chair: Joey Lau-Börjesson
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Eyelets in diabetes research and clinic
Per-Olof Berggren, Karolinska Institutet, Sweden
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Metabolic imaging of adipose tissue in diabetes
Kirsi Virtanen, University of Eastern Finland, Finland
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09.45 - 10.45 Oral abstract presentations
Chair: Lena Eliasson
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Infections and islet disease
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Magdalena A Mazur Type III interferons (IFNλs) are expressed in the human type 1 diabetes pancreas at disease onset, upregulate HLA class I expression and protect beta cells from Coxsackievirus infection
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Carmen Herrera Hidalgo Neonatal infections alter islet maturation and long-term glucose homeostasis
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Kristel Parv Phagocytosis and efferocytosis by pancreatic macrophages
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Virginia M Stone A hexavalent vaccine covering all Coxsackievirus B (CVB) serotypes protects against acute CVB infection and CVB-induced diabetes in mice
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Isabel Diaz Lozano Identifying novel biomarkers for virus-induced diabetes using an experimental animal model
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10.45 - 11.15 Coffee break and exhibition
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11.15 - 12.00 The Swedish Child Diabetes Foundation's Johnny Ludvigsson Nordic Prize lecture:
Chair: Johnny Ludvigsson
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Quality of care – the answer is blowing in the registries
Jannet Svensson, Copenhagen University Hospital, Denmark
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12.00 - 12.45 The Swedish Child Diabetes Foundation's Johnny Ludvigsson
Prize to a Young Swedish Scientist lecture:
Chair: Johnny Ludvigsson
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Beta-cell replacement in type 1 diabetes
Joey Lau Börjesson, Uppsala University, Sweden
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12.45 - 14.00 Lunch and exhibition
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13.30 - 14.00 Lunch seminar on academic innovations
Patrik Blomquist, KI Innovation, Stockholm, Sweden
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14.00 - 15.15 Session 3: Pathophysiology and prevention of type 1 diabetes
Chair: Malin Flodström-Tullberg
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Beta cell stress and development of Type 1 diabetes
Johnny Ludvigsson, Linköping University, Sweden
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Viruses and type 1 diabetes - prospects for prevention
Heikki Hyöty, University of Tampere, Finland
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15.15 - 15.45 Coffee break and exhibition
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15.45 – 17.00 Oral presentations (two parallel sessions)
Hall 1 - Type 2 diabetes and LADA – clinical aspects
Chair: Daniel Andersson
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Maria Houborg Petersen High intensity interval training combining biking and rowing markedly improves insulin sensitivity, body composition and VO2max
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Maria Hornstrup Christensen Future health and gestational diabetes - the FUDGE study
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Anna P Westberg The impact of maternal weight in pregnancy on glucose tolerance and insulin resistance in non-diabetic offspring
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Sofia Carlsson Type 2 diabetes and occupation; professional drivers, manufacturing workers and cleaners are at high risk; evidence from all Swedish employees 2006-2015
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Nikolaos Tertipis High-throughput metabolomics for early detection of individuals at increased risk for type 2 diabetes
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Ingrid K Hals Insulin treatment vs. sitagliptin does not affect deterioration of insulin secretion in LADA patients. Results from a 21 month randomized study
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Rebecka Hjort Physical activity and genetic susceptibility in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes
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Hall 2 - Immunological aspects of type 1 diabetes
Chair: Johanna Lempainen
Louise Magnusson Identification of altered immune cell subsets in patients with autoimmune endocrine diseases by mass cytometry
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Zhengkang Luo Kinetics of immune cell responses in the multiple low dose streptozotocin mouse model of type 1 diabetes
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Fabricia Dietrich Immunological effects of GAD-alum injection into the lymph node in recent onset type 1 diabetes
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Hugo Barcenilla Mass cytometry identifies regulatory T and Natural Killer cell subsets that are increased in individuals at high risk for type 1 diabetes
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Camilla Skoglund Increased levels of neutrophil extracellular trap (NET) remnants as well as mitochondrial and nuclear DNA in newly diagnosed type 1 diabetes children
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Kailash Singh Role of regulatory B cells in clinical and experimental type 1 diabetes
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17.15 - 18.30 Session 4: Clinical Science and Care
Chair: Per-Ola Carlsson
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Glucose sensor technologies in the management of type 1 diabetes
Jan Bolinder, Karolinska Institutet, Sweden
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Insulin pumps, from simple injection aid to advanced technology
Anders Frid, Lund University, Sweden
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18.30 – 19.15 General assembly of SSSD. Presentation of next year´s meeting
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19.30 Congress Dinner World Trade Center
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Friday April 12th
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08:30 – 09:00 Session 4: Clinical Science and Care, continued
Chair: Per-Ola Carlsson
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News from the Swedish National Diabetes Register (NDR)
Soffia Gudbjörnsdottir University of Gothenburg, Sweden
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09.00 - 09.30 SSSD Young Investigator Awards
Chair: Björn-Olav Åsvold
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Insulin secretion depends on intra-islet glucagon signaling
Berit Svendsen, University of Copenhagen, Denmark
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Sodium glucose transporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study
Peter Ueda, Karolinska Institutet, Sweden
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09.30 - 10.45 Session 5: Metabolism and inflammation in type 2 diabetes
Chair: Anna Krook
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Novo Nordisk Foundation Award Lecture:
Incretin therapy - Lessons learned and future directions
Bo Ahren, Lund University, Sweden
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Human adipose tissue and metabolic health
Kirsty Spalding, Karolinska Institutet, Sweden
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10.45 - 11.15 Coffee break (sponsored by AstraZeneca)
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11.15 - 12.30 Session 6: Precision Medicine and Drug Discovery
Chair: Olov Andersson
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Translational studies to enable tailored treatment of type 2 diabetes
Anders Rosengren. University of Gothenburg, Sweden
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Towards the development of microfluidic multi-tissue models for diabetes research and drug discovery
Volker Lauschke, Karolinska Institutet, Sweden
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12.30 - 12.45 Closing of the meeting
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12.45 Lunch and farewell